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HIGH-PROFILE COMPUTER BREACHES DRAW ATTENTION TO SECURITYSource: Buying pentasa onlinePosted on May 3, 2006 In December, when an intruder breached the security of two Iowa State University computers containing encrypted credit card numbers of athletics department donors and Social Security numbers of more than 3,000 university employees, it prompted a swift investigation and immediate notification of those whose personal data may have been obtained, and caused many worries along the way. An investigation determined that the intruder hacked into the computers not to steal personal information but to store and distribute pirated movies or music. Nevertheless, the incident prompted efforts over the past four months to tighten security around sensitive information and a greater awareness among students, faculty and non-information technology staff that the threat of an attack exists and it is up to the entire university community to prevent another incident. "Until something happens, people don't always believe that it can happen," said Maury Hope, associate chief information officer in Information Technology Services at Iowa State. Incidents such as the one at Iowa State have created greater awareness nationwide of the widespread threat of computer security breaches. According to a recent FBI survey of more than 2,000 businesses in Iowa, Nebraska, New York and Texas, nearly nine out of 10 suffered from a computer virus, spyware or other online attack in 2004 or 2005. Though most companies use security software, computer hacking techniques are also far ahead of what they were 18 months ago, according to Loras Even, managing director of RSM McGladrey Inc.'s Integrated Technology Solutions. "If you block them, they're going to try to find a way to bypass it," he said. Federal legislation such as the Gramm-Leach-Bliley and Sarbanes-Oxley acts, as well as mandatory reporting legislation in several states, has brought more attention to the issues surrounding security and provided those in the security industry with more leverage in approaching and addressing these issues in the corporate sector, according to Kip Peters, enterprise information protection vice president for FBL Financial Group Inc. He now considers computer security an essential part of doing business.
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Asacol, which is mesalamine - derivative of 5-aminosalicylic acid. It is prsecribed for treatment and remission maintenance at patients with ulcer colitis (earlier known as nonspecific ulcer colitis) of mild and moderate type.
Generic mesalamine dosage and dose escalation. A meta-analysis found that high-dose of mesalamine significantly reduced poststroke neurological dysfunction. It also showed improvement in cognitive impairment compared to placebo on at least one measure, and reduced blood viscosity. The dose escalation protocol of this drug seems to be well tolerated with a short time to peak concentration. Lactate, or lactate dehydrogenase, is the enzyme that converts lactate into lactic acid, the active metabolite, and has been linked to cerebral blood flow impairment in stroke and ischemia of the brain. Lactate has been studied in multiple stroke and traumatic brain injury trials. Clinical trials have found that in patients with ischemic stroke, blood lactate levels increase approximately 50% after 48 hours injury. The effects of long-term treatment on blood lactate seem to be temporary. Oral administration of 5 percent lactate solution decreased the infarct volume and brain blood flow compared to a 10% lactate solution. These effects were short-lived. In one study, an oral dose of 50 percent lactate showed an increase in the lactate clearance from CSF. In one study where a 50 percent lactate solution was given after TBI, the effect was maintained for 7 days. There was no statistically significant differences in neurological outcome the two studies. Oral administration of lactate in acute ischemic stroke appears to be a safe intervention. The only side effects reported were nausea and gastrointestinal complaints. The lactate was not reported to affect blood glucose, pressure, or heart rhythm. However, lactate is associated with some gastrointestinal side effects, including diarrhea, vomiting, and abdominal discomfort. There are not a lot of studies on lactate after TBI, but the authors reported that this is likely a small subset of TBI. One trial reported that a small group of patients who received intravenous lactate showed a significant improvement in functional testing (p=0.01). The authors also stated that lactate administration might improve cerebral blood flow. There are no major contraindications to the administration of a lactate solution. Lactate has been tested with oral administration in numerous stroke treatments. Most trials have been in children, adolescents, and adults. The only downside to lactate administration is that it needs additional hospitalization. Pregabalin (Reglan, Taperon) has several different potential side effects associated with its use. The most significant side effect with reglan is drowsiness. The drug metabolized into norreglan. However, one study reported that in patients on anti-nauseants, no sedating effects were seen; on the other hand, patients took twice the prescribed dose of norepinephrine, and therefore should not take reglan if they are on anti-drowsy/paraxial anti-nauseants or nonsteroidal anti-inflammatory drugs (NSAIDS). The other potential side effects of reglan include dry mouth, eye, and blurred vision. However, in the treatment of acute ischemic stroke after head trauma, oral administration of reglan appears to be well tolerated in both adults and children with low blood lactate without any adverse effects. The study reports that in a prospective treatment of large retrospective cohort 4,800 patients, oral administration of reglan increased plasma lactate for up to 72 hours is asacol the same as mesalamine after TBI when compared to an amenable standard therapy. In an open-label trial comparing the effect of diclofenac vs. a comparator dose of diclofenac administered as a systemic drug, no difference on patient outcomes was noted between diclofenac, which contains the anti-inflammatory drug ibuprofen, and comparator, the nonsteroidal proton pump inhibitor, Nifedipine. Neither diclofenac nor with ibuprofen has any significant therapeutic effect in patients with severe ischemic stroke. Therefore, these trials don't support the use of any diclofenac or ibuprofen as a systemic drug in patients with very early symptomatic stroke, and don't show how the diclofenac and ibuprofen effects on brain function compare to, nor do they show how systemic diclofenac and/or ibuprofen affects brain function in patients with later in-course ischemic stroke. There are a few studies that have looked at the use of naltrexone in rehabilitation patients with major traumatic brain injury. There is some evidence to suggest that naltrexone might reduce the time since injury in some patients and is associated with a how much is mesalamine without insurance better neurological outcome compared to placebo. However, there is not enough evidence to suggest its use for the treatment of ischemic stroke, particularly for older subjects. The drug is used to treat alcoholism and.
A computer security breach presents any organization with serious consequences, Even said. Customers and other outsiders may begin to question how safe and secure the organization and its information-protection systems may be. Businesses often face significant expenses in correcting the damage. According to the FBI study, the reported attacks inflicted an average of $24,000 in damages. Businesses may also face regulatory issues in correcting the problem. Many companies have addressed computer security by taking an "outside-in" approach Ð first building up a secure perimeter before turning to insider security threats, which accounted for 44 percent of the attacks documented in the FBI study. But changes in the corporate culture, such as an increase in telecommuters, make it nearly impossible to function with a heavily armored perimeter. "The perimeter is less defined, so now we're starting to look at what's going on inside (the company) a little different than in the past," Peters said. The best response, he said, is to use multiple layers of security to protect those lines of communications as much as possible without impairing communication. Even stresses the importance of educating people at all levels of an organization about computer security threats, and advises employees at all levels to be alert to suspicious e-mails or phone calls. All organizations should have some sort of incident response procedures, he added "As much as you train people and as many technology-based security measures you have in place, eventually an incident of some sort is going to occur, and it's better to have a planned response," Even said. But Hope and Peters say one of the greatest threats to corporate computer security today is the home computer. Most individuals today have broadband Internet access, which leaves home computers far more vulnerable to hackers. It becomes particularly worrisome for security specialists when people take their work home for the night or weekend, either on a laptop, disk or CD or by sending it via e-mail, sometimes leaving protected information, such as private client data, vulnerable to hackers. "You put that on a home computer and that, to me, is one of the things I really worry about because we have no control over it," Peters said.
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